leukotriene a 4 การใช้

• "' Ubenimex "'( leukotriene A 4 hydrolase ( a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities ), alanyl aminopeptidase ( aminopeptidase M / N ), leucyl / cystinyl aminopeptidase ( oxytocinase / vasopressinase ), and membrane dipeptidase ( leukotriene D 4 hydrolase ).
• 5-Lipoxygenase ( 5-LO ) uses FLAP to convert arachidonic acid into 5-hydroperoxyeicosatetraenoic acid ( 5-HPETE ), which spontaneously leukotriene A 4 ( LTA 4 ), an unstable epoxide . 5-HETE can be further metabolized to 5-oxo-ETE and 5-oxo-15-hydroxy-ETE, all of which have pro-inflammatory actions similar but not identical to those of LTB 4 and mediated not by LTB 4 receptors but rather by the OXE receptor ( see 5-Hydroxyicosatetraenoic acid and 5-oxo-eicosatetraenoic acid ).